28 Days Later is a 2002 British horror film directed by Danny Boyle. The screenplay was written by Alex Garland, and the film stars Cillian Murphy, Naomie Harris, Brendan Gleeson, Megan Burns, and Christopher Eccleston. The plot depicts the breakdown of society following the accidental release of a highly contagious "rage" virus and focuses upon the struggle of four survivors to cope with the ruination of the life they once knew.
A critical and commercial success, the film is widely recognised for images of a deserted London, and was shot almost entirely on digital video. The film spawned a 2007 sequel, 28 Weeks Later, a graphic novel entitled 28 Days Later: The Aftermath, which expands on the timeline of the outbreak, and a 2009 comic book series 28 Days Later.
British animal liberation activists break into a laboratory and are caught by a scientist while trying to free some chimpanzees being used for medical research. Despite the warnings of the chief scientist that the chimps are infected with a virus dubbed "Rage", which he claims is highly contagious and only takes one bite to spread, the activists open the cages anyway and release the chimpanzees. A chimp attacks a female activist and immediately infects her, and she in turn infects the other members of the group, including the chief scientist when he attempts to kill her.
Four weeks later, a bicycle courier named Jim (Cillian Murphy) awakens from a coma in a deserted hospital. As he leaves, he discovers London deserted and with signs of catastrophe. Jim is soon discovered and chased through the streets by psychotic people before being rescued by two survivors, Selena (Naomie Harris) and Mark (Noah Huntley), who kill Jim's pursuers with Molotov cocktails and explosives. After, they rush him to their hideout in the London Underground. There they reveal that while Jim was comatose from his accident, a virus spread uncontrollably among the populace, turning most people into rabid, psychotic "Infected", resulting in societal collapse. They also explain that Infection has been reported in Paris and New York. Selena and Mark accompany Jim to his parents' house the next morning, where he discovers that they committed suicide, leaving a note for him. That night, two of the Infected detect and attack the survivors in the house, and when the fight ends Selena kills Mark when she realises he has been bitten and likely infected; she explains that the infection is spread through the blood and overwhelms its victims in seconds and warns Jim that should he ever be infected, she would kill him "in a heartbeat". After leaving, they discover two more survivors, Frank (Brendan Gleeson) and his teenage daughter, Hannah (Megan Burns), holed up in a block of flats, and are invited to spend the rest of the night.
Frank informs them the next day that supplies, particularly water, are dwindling, and plays them a pre-recorded radio broadcast apparently transmitted by an Army blockade near Manchester, who claim to have "the answer to infection" and invites any survivor to try and reach their safe haven. The survivors board Frank's cab in search of the signal source and during the trip bond with one another in various situations. When the four reach the deserted blockade, Frank is infected when a drop of blood from a dead body falls into his eye. As he succumbs, he is killed by the arriving soldiers, who then take the remaining group to a fortified mansion under the command of Major Henry West (Christopher Eccleston). After settling in the mansion, West promises the three protection from the Infected. However, Jim quickly discovers that West's "answer to infection" involves waiting for the Infected to starve to death, and his broadcast of the radio message was launched to attract female survivors into sexual slavery to rebuild the population with his platoon's members. Jim attempts to escape with Selena and Hannah, but is captured by the soldiers, along with a Sergeant Farrell (Stuart McQuarrie), who disagrees with the major's plan and tried to stop the other soldiers from raping the two women. During their imprisonment, Farrell theorises that there is no worldwide pandemic, but rather that Great Britain has been quarantined.
The next day, as two soldiers lead Jim and Farrell to be executed, Selena and Hannah are being prepared for rape. Jim manages to escape while his escorts quarrel after killing Farrell, and notices the contrail of a jet aircraft flying high overhead, which largely confirms Farrell's theory. After luring West and one of his men to the blockade and ambushing them, Jim runs back to the soldiers' headquarters where he unleashes Mailer, an infected soldier that West kept chained outside for observation. Mailer attacks the soldiers in the mansion, while Jim sets out to rescue the girls, who had been split up in the chaos. Selena, held hostage by a surviving soldier, is then rescued by Jim, who arrives and savagely kills her captor with his bare hands. Selena mistakes Jim for an infected and raises her machete to kill him, but when she hesitates, Jim remarks "That was longer than a heartbeat." The two kiss, reunite with Hannah, and run to Frank's cab, only to encounter a vengeful West, who shoots Jim in the stomach. Hannah commandeers the cab and backs it up to the front door, where Mailer drags West out through the rear window and kills him. She then drives away with Jim and Selena.
Selena and Hannah rush Jim into a deserted hospital, where Selena performs life-saving emergency procedures. Twenty-eight days later, Jim is shown waking up in recovery again, this time at a remote cottage. Downstairs, he finds Selena sewing large swaths of fabric when Hannah appears. The three rush outside and unfurl a huge cloth banner, adding the final letter to the word "HELLO" laid out on the meadow. As a Finnish fighter jet flies over the landscape, Infected are shown lying by the side of a road, dying of starvation. The jet flies past the three waving survivors and their distress sign, and as it flies away Selena asks "Do you think he saw us this time?"
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